Signaling Lymphocytic Activation Molecule Family Member 1 Phospho-Tyr281 (SLAMF1 pY281) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Signaling Lymphocytic Activation Molecule Family Member 1 Phospho-Tyr281 (SLAMF1 pY281) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032024
tested applications
ELISA, DB
Description
SLAMF1 is a high-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (pYPN11) dependent signal transduction operates.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Signaling Lymphocytic Activation Molecule Family Member 1 Phospho-Tyr281 (SLAMF1 pY281) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr281 |
| Recommended Dilution | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, DB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13291 |
| Alias | Signaling lymphocytic activation molecule,SLAM,CD150,CDw150,IPO-3,SLAM family member 1 |
| Background | Antibody anti-SLAMF1 |
| Status | RUO |
Descripción
SLAMF1, also known as CD150, is a membrane glycoprotein and member of the signaling lymphocytic activation molecule (SLAM) family, which plays a critical role in modulating immune responses. It is encoded by the SLAMF1 gene and is primarily expressed on the surface of several immune cells, such as T cells, B cells, macrophages, and dendritic cells. SLAMF1 functions as a self-ligand, allowing it to engage in homophilic interactions that are essential for intercellular communication in immune responses. It influences a variety of immune processes, including cell activation, proliferation, cytokine production, and cytotoxic functions. This molecule plays a significant role in adaptive immunity by regulating immune cell interactions, positioning it as a critical factor in the immune response to pathogens and in autoimmune conditions.
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