Human Signal-transducing adaptor protein 2 (STAP2) ELISA Kit

Product specifications

ELISA Kits

Signal-transducing adaptor protein 2 (STAP2)

Human

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q9UGK3

STAP-2,Breast tumor kinase substrate,BRK substrate,STAP2,BKS

Elisa kits for STAP2

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Signal-transducing adaptor protein 2 (STAP2) is an adaptor protein that plays a significant role in intracellular signaling pathways by linking various receptors to downstream effectors, particularly within immune and inflammatory responses. It contains a PH domain, SH2 domain, and a proline-rich region, which facilitate its interaction with tyrosine-phosphorylated proteins and its localization to membrane-associated signaling complexes. STAP2 is implicated in the regulation of cytokine signaling pathways, such as those mediated by STAT3 and STAT5, influencing processes like cell survival, proliferation, and differentiation. It has been shown to interact with components of the T-cell receptor complex and Fc receptors, modulating immune responses and contributing to signal transduction in lymphocytes and macrophages. Dysregulation of STAP2 expression has been linked to pathological conditions, including autoimmune diseases, chronic inflammation, and cancer, where it may promote oncogenic signaling or alter immune surveillance. Additionally, STAP2 has been associated with metabolic regulation, as it can influence insulin signaling and adipocyte differentiation. Post-translational modifications of STAP2, such as phosphorylation and ubiquitination, regulate its activity and interaction networks, highlighting its role as a versatile adaptor in multiple signaling contexts.

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