Human Sialic Acid Binding Ig Like Lectin 6 (SIGLEC6) Protein
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Description
Human Sialic Acid Binding Ig Like Lectin 6 (SIGLEC6) Protein is a recombinant protein produced in Sf9, Baculovirus cells.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Sialic Acid Binding Ig Like Lectin 6 (SIGLEC6) |
| Host | Insect |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | CD327,CD33L,OBBP1,CD33L1,CD33L2,CDW327,Obesity-binding protein 1,CD33 antigen-like 1 |
| Background | Protein SIGLEC6 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SIGLEC6 is a member of the sialic acid-binding immunoglobulin-like lectin family, predominantly expressed on B cells, placental trophoblasts, and certain immune cells like mast cells. It binds to sialylated glycans, including α2,6-linked sialic acids, with high affinity for sialyl Tn antigen and leptin. SIGLEC6 functions as an inhibitory receptor, containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail that downregulates cellular activation pathways upon ligand binding. It plays a role in immune modulation, promoting tolerance during pregnancy by modulating trophoblast and maternal immune interactions. Dysregulation of SIGLEC6 has been implicated in gestational disorders like preeclampsia. Recent studies suggest its involvement in mast cell-mediated allergic responses and its potential as a therapeutic target in immune and metabolic disorders.
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