Human Sialic Acid-Binding Ig-Like Lectin 15 (SIGLEC15) Protein
312€ (20 µg)
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935106861
info@markelab.com
name
Human Sialic Acid-Binding Ig-Like Lectin 15 (SIGLEC15) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694240
tested applications
SDS-PAGE
Description
Human Sialic Acid-Binding Ig-Like Lectin 15 (SIGLEC15) Protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 28.82 kDa Observed MW (SDS-PAGE): 35 kDa Sequence Fragment: Met1-Thr263 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >95% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | Q6ZMC9 |
| OMIM | 61815 |
| Alias | CD33L3,HsT1361,SIGLEC-15,CD33 antigen-like 3 |
| Background | Protein SIGLEC15 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SIGLEC15 is predominantly expressed on macrophages, dendritic cells, and osteoclasts. Unlike other Siglecs, SIGLEC15 shows specificity for modified sialic acids and is crucial for osteoclast development and bone resorption. It interacts with ligands on T cells to regulate immune responses, making it a potential target for cancer immunotherapy as it suppresses anti-tumor immunity. SIGLEC15 is highly expressed in the tumor microenvironment and has been associated with poor prognosis in certain cancers. Its roles extend to tissue remodeling and maintaining immune homeostasis in non-inflammatory conditions.
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