Human Sialic Acid-Binding Ig-Like Lectin 15 (SIGLEC15) Protein

Este producto es parte de SIGLEC - sialic acid binding Ig like lectin
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312€ (20 µg)

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935106861
info@markelab.com
name
Human Sialic Acid-Binding Ig-Like Lectin 15 (SIGLEC15) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694240
tested applications
SDS-PAGE

Description

Human Sialic Acid-Binding Ig-Like Lectin 15 (SIGLEC15) Protein is a recombinant Human protein expressed in HEK293 cells.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Host
HEK293 cells
Origin
Human
Observed MW
Molecular Weight: Calculated MW: 28.82 kDa  Observed MW (SDS-PAGE): 35 kDa
Sequence Fragment: Met1-Thr263
Tag: C-terminal His tag
Expression
Recombinant
Purity
>95% (SDS-PAGE)
Size 1
20 µg
Size 2
100 µg
Form
Lyophilized Reconstitute in sterile H2O. Do not vortex.
Tested Applications
SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80.
Availability
Shipped within 5-15 working days.
Storage
Store lyophilized between -20 °C and -80 °C.
Dry Ice
No
UniProt ID
Q6ZMC9
OMIM
61815
Alias
CD33L3,HsT1361,SIGLEC-15,CD33 antigen-like 3
Background
Protein SIGLEC15
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

SIGLEC15 is predominantly expressed on macrophages, dendritic cells, and osteoclasts. Unlike other Siglecs, SIGLEC15 shows specificity for modified sialic acids and is crucial for osteoclast development and bone resorption. It interacts with ligands on T cells to regulate immune responses, making it a potential target for cancer immunotherapy as it suppresses anti-tumor immunity. SIGLEC15 is highly expressed in the tumor microenvironment and has been associated with poor prognosis in certain cancers. Its roles extend to tissue remodeling and maintaining immune homeostasis in non-inflammatory conditions.
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