Human Sialic Acid Binding Ig Like Lectin 14 (SIGLEC14) Protein
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935106861
info@markelab.com
Precio
212.5€ (10 µg)
Protein SIGLEC14
proveedor
Abbexareference
abx069066Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Sialic Acid Binding Ig Like Lectin 14 (SIGLEC14) is a recombinant Human protein produced in E. coli using Prokaryotic expression.
Background
SIGLEC14 is a member of the Siglec family expressed on myeloid cells, including monocytes and neutrophils. It is paired with SIGLEC5, with which it shares high sequence similarity, forming an activating counterpart to the inhibitory SIGLEC5. SIGLEC14 binds to sialic acid-containing glycans on pathogens and self-tissues, triggering pro-inflammatory responses. This protein has been implicated in innate immune activation, particularly in recognizing bacterial infections. SIGLEC14 also plays a role in the modulation of immune responses, balancing activation and tolerance. Genetic variations in SIGLEC14 can result in a fusion with SIGLEC5, altering its expression and immune function.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Sialic Acid Binding Ig Like Lectin 14 (SIGLEC14)
host
E. coli
conjugation
Unconjugated
form
Lyophilized
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SIGLEC14
dry ice
No
availability
Shipped within 5-12 working days.
alias
Siglec-14
uniprot id
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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