Human Sialic Acid Binding Ig Like Lectin 14 (SIGLEC14) Protein

Este producto es parte de SIGLEC - sialic acid binding Ig like lectin
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221€ (10 µg)

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935106861
info@markelab.com
name
Human Sialic Acid Binding Ig Like Lectin 14 (SIGLEC14) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069066
tested applications
WB, SDS-PAGE

Description

Recombinant Sialic Acid Binding Ig Like Lectin 14 (SIGLEC14) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Sialic Acid Binding Ig Like Lectin 14 (SIGLEC14)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 19.1 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Gln24-Leu137
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-12 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q08ET2
Alias
Siglec-14
Background
Protein SIGLEC14
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

SIGLEC14 is a member of the Siglec family expressed on myeloid cells, including monocytes and neutrophils. It is paired with SIGLEC5, with which it shares high sequence similarity, forming an activating counterpart to the inhibitory SIGLEC5. SIGLEC14 binds to sialic acid-containing glycans on pathogens and self-tissues, triggering pro-inflammatory responses. This protein has been implicated in innate immune activation, particularly in recognizing bacterial infections. SIGLEC14 also plays a role in the modulation of immune responses, balancing activation and tolerance. Genetic variations in SIGLEC14 can result in a fusion with SIGLEC5, altering its expression and immune function.

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