Human Sialic acid-binding Ig-like lectin 11 (SIGLEC11) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human Sialic acid-binding Ig-like lectin 11 (SIGLEC11) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Sialic acid-binding Ig-like lectin 11 (SIGLEC11) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Sialic acid-binding Ig-like lectin 11 (SIGLEC11) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q96RL6 |
| OMIM | 607157 |
| Alias | Sialic acid-binding lectin 11,Siglec-11 |
| Background | Elisa kits for SIGLEC11 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SIGLEC11 is expressed predominantly in microglial cells in the brain and interacts with sialylated structures on neurons. It is unique among Siglecs for its role in modulating neuroinflammatory responses and maintaining neuronal integrity. Evolutionary studies show its expansion in humans, suggesting specialized functions in brain immunity and neuroprotection.
Related Products
Sialic Acid Binding Ig Like Lectin 11 (SIGLEC11) Antibody
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIM). SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. Sequence analysis predicted that the 697-amino acid SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and four C2-set Ig-like domains, five potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8. Expression was also detected on monocytes and a CD16-positive/CD56-negative natural killer-like lymphocyte population. After sialidase treatment, which is necessary for unmasking the sialic acid-binding site on SIGLECs interacting with cell surface sialic acids, cells expressing SIGLEC10 bound to red blood cells. Immunoprecipitation analysis indicated expression of a 100 to 120-kD monomeric protein, higher than the predicted molecular mass, suggesting that SIGLEC10 is glycosylated.
Ver Producto
Sialic Acid Binding Ig Like Lectin 11 (SIGLEC11) Antibody
SIGLEC11 Antibody is a Rabbit Polyclonal against SIGLEC11.
Ver Producto
Human Sialic acid-binding Ig-like lectin 11 (SIGLEC11) ELISA Kit
Human Sialic acid-binding Ig-like lectin 11 (SIGLEC11) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Sialic acid-binding Ig-like lectin 11 (SIGLEC11) concentrations in tissue homogenates, cell lysates and other biological fluids.
Ver Producto