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Human Semaphorin 3B (SEMA3B) ELISA Kit
proveedor
Abbexareference
abx251535Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Semaphorin 3B (SEMA3B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Semaphorin 3B concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Background
Semaphorins constitute a large family of cell surface and secreted guidance molecules, categorized into eight classes due to their structural variations, They show a conserved sema domain in their N-terminal region. They primarily function as short-range inhibitory signals, particularly crucial in directing axons away from inappropriate areas, especially during neural system development. Plexins are the primary receptors for semaphorins, often working alongside neuropilins as co-receptors in receptor complexes. These molecules have various roles, and some classes of semaphorins (SEMA3,SEMA4,SEMA4,SEMA6 ,SEMA7)are found in vertebrates, contributing to processes like atherosclerosis by affecting endothelial function, leukocyte infiltration, monocyte-macrophage retention, platelet hyperreactivity, and neovascularization. SEMA3B serves as an inhibitor of axonal extension and has demonstrated its role as a tumor suppressor by promoting apoptosis. Different transcript variants are produced due to alternative splicing of this gene. It is known by various aliases, including SemA, SEMA5, SEMAA, semaV, and LUCA-1.
Background
Las semaforinas constituyen una gran familia de moléculas guía secretadas y de superficie celular, clasificadas en ocho clases debido a sus variaciones estructurales. Muestran un dominio sema conservado en su región N-terminal. Funcionan principalmente como señales inhibidoras de corto alcance, particularmente cruciales para alejar los axones de áreas inapropiadas, especialmente durante el desarrollo del sistema neuronal. Las plexinas son los receptores principales de las semaforinas y a menudo trabajan junto con las neuropilinas como correceptores en complejos receptores. Estas moléculas tienen varias funciones y algunas clases de semaforinas (SEMA3, SEMA4, SEMA4, SEMA6, SEMA7) se encuentran en los vertebrados y contribuyen a procesos como la aterosclerosis al afectar la función endotelial, la infiltración de leucocitos, la retención de monocitos y macrófagos, la hiperreactividad plaquetaria y la neovascularización. . SEMA3B actúa como inhibidor de la extensión axonal y ha demostrado su papel como supresor de tumores al promover la apoptosis. Se producen diferentes variantes de transcripción debido al corte y empalme alternativo de este gen. Es conocido por varios alias, incluidos SemA, SEMA5, SEMAA, semaV y LUCA-1.
Características del producto
category
ELISA Kits
immunogen target
Semaphorin 3B (SEMA3B)
reactivity
Human
test range
1.56 ng/ml - 100 ng/ml
sensitivity
0.94 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
SemA,SEMA5,SEMAA,semaV,LUCA-1,Sema A(V),Semaphorin-V,Semaphorin-3B
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
SEMA3B
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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