Human P2Y Purinoceptor 1 (P2RY1) Protein
1872€ (1 mg)
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name
Human P2Y Purinoceptor 1 (P2RY1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654885
tested applications
WB, SDS-PAGE
Description
Human Purinergic Receptor P2Y, G Protein Coupled 1 (P2RY1) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | P2Y Purinoceptor 1 (P2RY1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | P2RY1,ATP receptor,P2 purinoceptor subtype Y1,P2Y purinoceptor 1,platelet ADP receptor ,Purinergic receptor P2Y1,P2Y ATP receptor 1,P2Y1 receptor,purinergic receptor P2Y,P2Y1, SARCC |
| Background | Protein P2RY1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
P2RY1 is a G protein-coupled receptor (GPCR) that binds extracellular nucleotides such as ADP, acting as a key player in platelet aggregation, neurotransmission, and vascular tone. It couples to Gq proteins, activating phospholipase C (PLC) and increasing intracellular calcium levels, which triggers platelet activation and aggregation in response to ADP. P2RY1 is widely expressed in platelets, the central nervous system, and endothelial cells, where it regulates hemostasis, blood clot formation, and vasodilation. In the CNS, P2RY1 modulates neuronal excitability and synaptic transmission. Dysregulation of P2RY1 signaling is associated with thrombosis, stroke, and neuroinflammatory conditions. P2RY1 antagonists are being developed as antithrombotic agents to prevent clot formation in cardiovascular diseases. Its critical role in platelet function, vascular regulation, and neuroprotection highlights P2RY1 as a therapeutic target for thrombotic disorders and neurological diseases.
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