Human Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) Protein

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
Product Graph
221€ (10 µg)

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935106861
info@markelab.com
name
Human Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167984
tested applications
WB, SDS-PAGE

Description

Human Tyrosine Phosphatase Receptor Type Q (PTPRQ) Protein is a recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 32.0 kDa  Observed MW (SDS-PAGE): 32 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Glu36-Thr294

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9UMZ3
Alias
DFNA73,DFNB84,DFNB84A,PTPGMC1,R-PTP-Q,Receptor-type tyrosine-protein phosphatase Q,Phosphatidylinositol phosphatase PTPRQ
Background
Protein PTPRQ
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

PTPRQ is a receptor-like protein tyrosine phosphatase that plays critical roles in hair cell function, auditory processes, and cellular signaling. Structurally, PTPRQ contains extracellular domains, a single transmembrane region, and an intracellular phosphatase domain with enzymatic activity. It is primarily expressed in sensory hair cells of the inner ear, where it regulates the structure and function of stereocilia, specialized actin-rich projections responsible for mechanotransduction. PTPRQ is essential for maintaining hair cell integrity and hearing function by modulating phosphatidylinositol signaling and dephosphorylating key targets. Mutations in PTPRQ are associated with autosomal recessive non-syndromic hearing loss, underscoring its importance in auditory physiology. Beyond the ear, PTPRQ also contributes to cellular adhesion, signaling, and cytoskeletal dynamics. Its dysfunction highlights its role in sensory processes and cellular regulation.

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