Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) Antibody
286€ (100 µl)
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935106861
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name
Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx129111
tested applications
WB, IHC, IF/ICC
Description
Protein Tyrosine Phosphatase Receptor Type Q Antibody is a Rabbit Polyclonal against Protein Tyrosine Phosphatase Receptor Type Q.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UMZ3 |
| Alias | DFNA73,DFNB84,DFNB84A,PTPGMC1,R-PTP-Q,Receptor-type tyrosine-protein phosphatase Q,Phosphatidylinositol phosphatase PTPRQ |
| Background | Antibody anti-PTPRQ |
| Status | RUO |
| Note | Concentration: 0.31 mg/ml - |
Descripción
PTPRQ is a receptor-like protein tyrosine phosphatase that plays critical roles in hair cell function, auditory processes, and cellular signaling. Structurally, PTPRQ contains extracellular domains, a single transmembrane region, and an intracellular phosphatase domain with enzymatic activity. It is primarily expressed in sensory hair cells of the inner ear, where it regulates the structure and function of stereocilia, specialized actin-rich projections responsible for mechanotransduction. PTPRQ is essential for maintaining hair cell integrity and hearing function by modulating phosphatidylinositol signaling and dephosphorylating key targets. Mutations in PTPRQ are associated with autosomal recessive non-syndromic hearing loss, underscoring its importance in auditory physiology. Beyond the ear, PTPRQ also contributes to cellular adhesion, signaling, and cytoskeletal dynamics. Its dysfunction highlights its role in sensory processes and cellular regulation.
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