Human Protein DENND6A (DENND6A) ELISA Kit

Este producto es parte de DENND - DENN domain containing
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715€ (96 tests)

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935106861
info@markelab.com
name
Human Protein DENND6A (DENND6A) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx510109
tested applications
ELISA

Description

Human Protein DENND6A (DENND6A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Protein DENND6A (DENND6A) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Protein DENND6A (DENND6A)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q8IWF6
Alias
AFI1A,FAM116A,DENN domain-containing protein 6A
Background
Elisa kits for DENND6A
Status
RUO
Note
Validity: The validity for this kit is 6 months.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

DENN domain containing 6A (DENND6A) is a member of the DENN domain family, acting as a guanine nucleotide exchange factor (GEF) for Rab GTPases, specifically Rab14. DENND6A regulates intracellular trafficking, including vesicle transport and endosomal recycling, by promoting the GDP-to-GTP exchange on Rab14. This activity is essential for processes like endocytic recycling of plasma membrane proteins, intracellular signaling, and maintenance of epithelial cell polarity. DENND6A also supports trafficking of cargo between endosomes and the Golgi apparatus, which is critical for protein sorting and secretion. Its expression is ubiquitous, with heightened activity in polarized cells such as neurons and epithelial tissues. Dysregulation of DENND6A has been linked to defects in intracellular transport, contributing to diseases such as cancer and neurological disorders, where disruptions in endosomal sorting and recycling lead to altered cellular signaling and polarity. DENND6A’s role in vesicle dynamics highlights its importance in maintaining cellular organization and adaptive responses.
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