Human Protein BRICK1 (BRK1) ELISA Kit
715€ (96 tests)
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name
Human Protein BRICK1 (BRK1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx392201
tested applications
ELISA
Description
Human Protein BRICK1 (BRK1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Protein BRICK1 (BRK1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Protein BRICK1 (BRK1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.12 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8WUW1 |
| Gene ID | 55845 |
| OMIM | 611183 |
| Alias | MDS027,hHBrk1,C3orf10,HSPC300,Protein BRICK5 |
| Background | Elisa kits for BRK1 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
BRICK1 subunit of SCAR/WAVE actin nucleating complex (BRK1) is a protein that is a part of the SCAR/WAVE complex, which regulates actin polymerization by activating the Arp2/3 complex The SCAR/WAVE complex, including BRICK1, is involved in initiating the formation of branched actin filaments, a process essential for cell movement, membrane ruffling, and cellular shape changes BRICK1 plays a role in promoting actin dynamics, particularly in immune cells where it influences processes such as T-cell activation, cell migration, and phagocytosis In addition, BRICK1 is important for neuronal development, where it helps regulate synaptic plasticity and dendritic spine morphology Disruption of BRICK1 or the SCAR/WAVE complex can lead to defects in cell motility, immune function, and nervous system development Abnormal regulation of actin dynamics due to BRICK1 dysfunction is implicated in various diseases, including autoimmune disorders, cancer metastasis, and neurodevelopmental disorders where impaired cellular movement and actin remodeling contribute to disease progression
