Human Chemerin ELISA

Product specifications

ELISA Kits

Human

Reference Material: recombinant chemerin
Incubation Period: 2.5h
Calibrator: recombinant chemerin
Controls: 2 controls lyophilised

Sandwich

0.005 – 303 [ng/L]

0.005 µg/L

1:505

Antibody: Mouse / Goat

96 det.

Elisa

Serum
EDTA / Heparin Plasma

3-5 days.

Shelf life: between 1 and 2 years
All reagents are stable until the indicated expiry, if stored unopened and protected from sunlight at 2 – 8°C

retinoic acid receptor responder protein 2,tazarotene-induced gene 2 protein,TIG2, RAR-responsive protein TIG2

Elisa Kits for: RARRES2

RUO

Intra/Interassay Variance [%]< 10

Descripción

Kit para la cuantificacion de Human Chemerin en muestras de suero y plasma humanos. Solo para investigación (RUO).

Chemerin, also known as tazarotene-induced gene 2 (TIG2) or retinoic acid receptor responder 2 (RARRES2), is synthesized as precursor protein of 163 amino acids including a N-terminal signal peptide of 20 amino acids, which is chipped of enduring secretion. The inactive, circulation proform of Chemerin contains six cystein residues and thus three intramolecular disulfide bridges are suggested. Prochemerin expression has been demonstrated for liver, lung, pituitary, lymph node, stomach and adipose tissue . It has been detected in blood, ascitic fluids from ovary and liver cancer and synovial fluids from arthritic patients. Different receptors have been found in spleen, lymph node, small intestine, lung tissue as well as in macrophages and immature dendritic cells. Prochemerin is converted into its biologically active form by serine or cystein proteases, resulting in pro- or anti-inflammatory actions of the active protein, respectively. Proteolytic cleavage of Chemerin has been described for following serine proteases tryptase, plasmin, elastase, cathepsin G as well as for the cystein proteases cathepsin S and calpains

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