Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) CLIA Kit

Este producto es parte de ALOX - Arachidonate lipoxygenase
Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) CLIA Kit

Pida mas información

935106861

info@markelab.com

Precio

845€ (96 tests)

CLIA Kits ALOX15

proveedor

Abbexa

reference

abx492200

Tested Applications

CLIA

reactivity

Human

status

RUO

clonality

Descripción

Human Arachidonate-15-Lipoxygenase (ALOX15) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.


Background

ALOX15 catalyzes the oxygenation of arachidonic acid and linoleic acid to generate 15(S)-hydroperoxyeicosatetraenoic acid [15(S)-HPETE] and 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE), respectively. These lipid intermediates are precursors for resolvins, protectins, and other specialized pro-resolving mediators (SPMs) involved in the resolution of inflammation. ALOX15 is highly expressed in reticulocytes, macrophages, and epithelial cells, where it plays roles in redox regulation, membrane remodeling, and anti-inflammatory responses. In macrophages, ALOX15 promotes the clearance of apoptotic cells (efferocytosis) and contributes to tissue homeostasis during inflammation resolution. Dysregulation of ALOX15 is associated with various pathological conditions, including asthma, atherosclerosis, diabetes, and neurodegenerative diseases. In cancer biology, ALOX15 has dual roles, acting as both a tumor suppressor by inhibiting proliferation and a pro-tumorigenic factor in specific contexts. Its ability to generate lipid mediators essential for resolving inflammation highlights its therapeutic potential in chronic inflammatory and metabolic disorders.

Características del producto

category

CLIA Kits


immunogen target

Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15)


reactivity

Human


test range

1.56 ng/ml - 100 ng/ml


sensitivity

< 0.55 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Chemiluminescent


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

ALOX15,LOG15


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

ALOX15


dry ice

No


note

The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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