Human PHD Finger Protein 8 (PHF8) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PHF8
proveedor
Abbexareference
abx538676Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human PHD Finger Protein 8 (PHF8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PHD Finger Protein 8 (PHF8) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PHF8 is a histone demethylase containing a PHD finger domain that recognizes H3K4me3 and demethylates repressive marks such as H3K9me2/1 to activate transcription. It plays a role in gene regulation during cell cycle progression, neuronal development, and DNA damage repair by promoting chromatin accessibility. PHF8 is expressed in neural tissues and contributes to neurogenesis, synaptic plasticity, and cognitive function. Mutations in PHF8 are associated with X-linked intellectual disability and cleft lip/palate syndromes, where impaired histone demethylation leads to defective gene expression during development. Dysregulation of PHF8 is also implicated in cancer, where it promotes tumor growth and proliferation through transcriptional activation of oncogenes. Knockdown studies demonstrate impaired DNA repair, cell cycle arrest, and defects in neuronal differentiation, highlighting its critical role in histone demethylation, chromatin regulation, and developmental processes.
Características del producto
category
ELISA Kits
immunogen target
PHD Finger Protein 8 (PHF8)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
JHDM1F,KDM7B MRXSSD,ZNF422,Histone lysine demethylase PHF8
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PHF8
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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