Human Paired Box Protein Pax-2 (PAX2) ELISA Kit
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Description
Human Paired Box Protein Pax-2 (PAX2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PAX2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Paired Box Protein Pax-2 (PAX2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q02962 |
| Gene ID | 5076 |
| OMIM | 120330 |
| Alias | FSGS7,PAPRS,PAX-2 |
| Background | Elisa kits for PAX2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PAX2 is a transcription factor that plays a crucial role in the development of the urogenital system, central nervous system, and the optic nerve by regulating cell proliferation, differentiation, and survival. PAX2 is highly expressed during nephrogenesis, where it guides the formation of kidney structures, including the ureteric bud and nephrons, and in optic development, where it contributes to retinal and optic nerve patterning. Mutations in PAX2 are linked to renal coloboma syndrome, characterized by kidney malformations, optic nerve hypoplasia, and hearing loss. PAX2 also functions as an oncogene in cancers such as renal cell carcinoma and ovarian cancer, where its aberrant expression promotes cell survival, proliferation, and resistance to apoptosis. Knockout studies in mice reveal impaired kidney development, absent optic nerves, and embryonic lethality, highlighting PAX2's essential roles in organogenesis, tissue morphogenesis, and cell lineage specification.
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