Human P2RY6 (P2Y purinoceptor 6 ) ELISA Kit
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Name
Human P2RY6 (P2Y purinoceptor 6 ) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH10834
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 31.25-2000pg/ml |
| Sensitivity | 18.75pg/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q15077 |
| Alias | P2RY6,uridine nucleotide receptor,P2Y6,P2Y ATP receptor 6,P2Y purinoceptor 6,pyrimidinergic receptor P2Y |
| Background | Elisa kits for P2RY6 |
| Status | RUO |
Background
P2RY6 is a G protein-coupled receptor activated by extracellular UDP (uridine diphosphate) and to a lesser extent UTP, mediating cellular responses to nucleotide release during tissue injury or inflammation. P2RY6 couples primarily to Gq proteins, leading to phospholipase C (PLC) activation, calcium mobilization, and downstream signaling that regulates inflammation, immune responses, and smooth muscle contraction. P2RY6 is widely expressed in immune cells, smooth muscle, and epithelial tissues, where it modulates cytokine production, chemotaxis, and vascular tone. In inflammation, P2RY6 plays a central role in recruiting immune cells and amplifying inflammatory signaling, contributing to diseases such as asthma, arthritis, and colitis. It is also involved in smooth muscle contraction in the vascular and gastrointestinal systems. Dysregulation of P2RY6 signaling is linked to chronic inflammatory diseases, cardiovascular dysfunction, and metabolic disorders. P2RY6 antagonists are being investigated as therapeutic agents for inflammation, asthma, and vascular diseases due to their role in regulating immune and smooth muscle responses.
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