Human Nucleotide Binding Oligomerization Domain Containing Protein 2 (NOD2) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for NOD2
proveedor
Abbexareference
abx258642Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Nucleotide Binding Oligomerization Domain Containing Protein 2 (NOD2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Nucleotide Binding Oligomerization Domain Containing Protein 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
CARD15, also known as NOD2 (Nucleotide-binding oligomerization domain containing 2), is a member of the NOD-like receptor (NLR) family, which is involved in the innate immune response. CARD15 plays a critical role in detecting bacterial components, such as muramyl dipeptide, which are found in the cell walls of certain bacteria. Upon activation, CARD15 triggers signaling pathways that lead to the activation of NF-κB and MAPK pathways, promoting the production of pro-inflammatory cytokines. This process is crucial for the immune system to respond to bacterial infections. Mutations in CARD15/NOD2 are associated with several diseases, particularly Crohn's disease, a form of inflammatory bowel disease (IBD), highlighting its role in regulating gut immune responses. Disruptions in CARD15 signaling can result in inappropriate immune activation, contributing to chronic inflammation and autoimmune disorders.
Características del producto
category
ELISA Kits
immunogen target
Nucleotide Binding Oligomerization Domain Containing Protein 2 (NOD2)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.06 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
NOD2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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