Human NOTCH4(Neurogenic locus notch homolog protein 4) ELISA Kit
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human NOTCH4(Neurogenic locus notch homolog protein 4) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH2222
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.313-20ng/ml |
| Size 1 | 96T |
| Sample Type | Serum,Plasma,Tissue homogenates,Other biological fluids |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 6 months |
| UniProt ID | Q99466 |
| Alias | INT3,notch receptor 4 |
| Background | Elisa Kits NOTCH4 |
| Status | RUO |
Neurogenic locus notch homolog protein 4 (NOTCH4) is a transmembrane receptor in the Notch family, crucial for cell-cell signaling in endothelial cells, where it regulates angiogenesis, vascular remodeling, and homeostasis It encodes a single-pass transmembrane protein with extracellular EGF-like repeats for ligand binding and an intracellular domain (NICD) that translocates to the nucleus upon activation Binding to ligands like Delta-like (DLL) or Jagged triggers proteolytic cleavages by ADAM proteases and gamma-secretase, releasing NICD to activate target genes such as HES and HEY, which control cell proliferation, differentiation, and apoptosis Dysregulation of NOTCH4 signaling is linked to cancers, particularly breast cancer and gliomas, due to its role in angiogenesis and metastasis It also modulates endothelial inflammation and immune responses Mutations or altered expression of NOTCH4 contribute to vascular abnormalities like arteriovenous malformations and pulmonary hypertension Genetic variations in NOTCH4 are associated with schizophrenia and autoimmune diseases like systemic lupus erythematosus, highlighting its importance in development and pathology
Related Products
Human NOTCH4(Neurogenic locus notch homolog protein 4) ELISA Kit
Ver Producto
Neurogenic Locus Notch Homolog Protein 4 (NOTCH4) Antibody
NOTCH4 Antibody is a Rabbit Polyclonal Antibody against NOTCH4.
Ver Producto
Neurogenic Locus Notch Homolog Protein 4 (NOTCH4) Antibody
Rabbit Polyclonal against the NOTCH4 protein.
Ver Producto