Human Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 (NCK1) Protein
234€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 (NCK1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx167977
Tested Applications
WB, SDS-PAGE
Description
Human Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 (NCK1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ala2-Ser377 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 46.4 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | NCK1, NCK, NCKalpha, nck-1, NCK adaptor protein 1 |
| Background | Protein NCK1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
NCK1 is a cytoplasmic adaptor protein containing three SH3 domains and one SH2 domain, which allows it to mediate interactions between receptor tyrosine kinases (RTKs) and downstream effectors in signaling pathways. NCK1 is involved in actin cytoskeleton reorganization, cell motility, and immune synapse formation by linking signaling proteins such as WASP, WAVE, and PAK1. It plays key roles in processes like cell migration, proliferation, and T-cell activation. NCK1 is highly expressed in various tissues and regulates growth factor receptor signaling, including pathways like MAPK/ERK and PI3K. Dysregulation of NCK1 is associated with cancer progression, metastasis, and immune system dysfunction. Knockout studies show defects in actin dynamics, impaired cell movement, and reduced T-cell activation, highlighting its importance in cytoskeletal signaling and cellular communication.
Productos relacionados
Cytoplasmic Protein NCK1 (NCK1) Antibody
NCK1 Antibody is a Rabbit Polyclonal antibody against NCK1. The protein encoded by this gene is one of the signaling and…
Ver producto
Cytoplasmic Protein NCK1 (NCK1) Antibody
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 …
Ver producto
Cytoplasmic Protein NCK1 (NCK1) Antibody
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 …
Ver producto