Human Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 (NCK1) Protein
234€ (10 µg)
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name
Human Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 (NCK1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167977
tested applications
WB, SDS-PAGE
Description
Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 (NCK1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 46.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala2-Ser377 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | NCK1, NCK, NCKalpha, nck-1, NCK adaptor protein 1 |
| Background | Protein NCK1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
NCK1 is a cytoplasmic adaptor protein containing three SH3 domains and one SH2 domain, which allows it to mediate interactions between receptor tyrosine kinases (RTKs) and downstream effectors in signaling pathways. NCK1 is involved in actin cytoskeleton reorganization, cell motility, and immune synapse formation by linking signaling proteins such as WASP, WAVE, and PAK1. It plays key roles in processes like cell migration, proliferation, and T-cell activation. NCK1 is highly expressed in various tissues and regulates growth factor receptor signaling, including pathways like MAPK/ERK and PI3K. Dysregulation of NCK1 is associated with cancer progression, metastasis, and immune system dysfunction. Knockout studies show defects in actin dynamics, impaired cell movement, and reduced T-cell activation, highlighting its importance in cytoskeletal signaling and cellular communication.
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