Human Neurotensin Receptor 2 (NTSR2) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein NTSR2
proveedor
Abbexareference
abx652198Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Neurotensin Receptor 2 (NTSR2) Protein is a Recombinant protein from Human.
Background
NTSR2 is a G protein-coupled receptor for neurotensin (NT), with lower affinity compared to NTSR1. NTSR2 is expressed in the central nervous system, including the spinal cord, midbrain, and peripheral tissues, where it regulates pain perception, neurotransmission, and immune responses. NTSR2 primarily couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating neuronal excitability and neurotransmitter release. NTSR2 plays a key role in antinociception, particularly in modulating chronic and neuropathic pain pathways. Compared to NTSR1, NTSR2’s effects are more focused on pain relief and anti-inflammatory responses, making it a promising target for analgesic therapies. Dysregulation of NTSR2 signaling is associated with chronic pain conditions and neuroinflammation. Selective NTSR2 agonists are being investigated for their potential to treat pain without the side effects associated with opioid analgesics. NTSR2’s role in pain modulation and inflammation positions it as a critical therapeutic target for analgesia and neuroimmune regulation.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Neurotensin Receptor 2 (NTSR2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 25.8 kDa Observed MW: 16 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala37-Pro241 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
NTSR2
dry ice
No
availability
Shipped within 5-7 working days.
alias
NTSR2,NTR2,levocabastine-sensitive neurotensin receptor,NTR2,high-affinity levocabastine-sensitive neurotensin receptor,neurotensin receptor type 2,NT2R
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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