Human Neurotensin Receptor 2 (NTSR2) Protein

221€ (10 µg)
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name
Human Neurotensin Receptor 2 (NTSR2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652198
tested applications
WB, SDS-PAGE
Description
Neurotensin Receptor 2 (NTSR2) Protein is a Recombinant protein from Human.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Neurotensin Receptor 2 (NTSR2) |
Host | E. coli |
Origin | Human |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 25.8 kDa Observed MW: 16 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala37-Pro241 Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 95% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | O95665 |
Alias | NTSR2,NTR2,levocabastine-sensitive neurotensin receptor,NTR2,high-affinity levocabastine-sensitive neurotensin receptor,neurotensin receptor type 2,NT2R |
Background | Protein NTSR2 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
NTSR2 is a G protein-coupled receptor for neurotensin (NT), with lower affinity compared to NTSR1. NTSR2 is expressed in the central nervous system, including the spinal cord, midbrain, and peripheral tissues, where it regulates pain perception, neurotransmission, and immune responses. NTSR2 primarily couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating neuronal excitability and neurotransmitter release. NTSR2 plays a key role in antinociception, particularly in modulating chronic and neuropathic pain pathways. Compared to NTSR1, NTSR2’s effects are more focused on pain relief and anti-inflammatory responses, making it a promising target for analgesic therapies. Dysregulation of NTSR2 signaling is associated with chronic pain conditions and neuroinflammation. Selective NTSR2 agonists are being investigated for their potential to treat pain without the side effects associated with opioid analgesics. NTSR2’s role in pain modulation and inflammation positions it as a critical therapeutic target for analgesia and neuroimmune regulation.
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