Human Neurotensin Receptor 1, High Affinity (NTSR1) Protein

Este producto es parte de NTSR - Neurotensin Receptor
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2093€ (1 mg)

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935106861
info@markelab.com
name
Human Neurotensin Receptor 1, High Affinity (NTSR1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654545
tested applications
WB, SDS-PAGE

Description

Human Neurotensin Receptor 1, High Affinity (NTSR1) Protein is a Recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Neurotensin Receptor 1, High Affinity (NTSR1)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 27.2 kDa  Observed MW (SDS-PAGE): 27 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Met1-Thr67
Tag: N-terminal His tag and TrxA tag
Expression
Recombinant
Purity
> 95%
Size 1
1 mg
Size 2
5 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.
Availability
Shipped within 1-2 months.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P30989
Gene ID
4923
OMIM
162651
Alias
NTSR1,NTR,NTR1,NTRH,neurotensin receptor type 1, Levocabastin-insensitive neurotensin receptor,NT-1R,neurotensin receptor 1 (high affinity)
Background
Protein NTSR1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

NTSR1 is a G protein-coupled receptor that binds neurotensin (NT), a neuropeptide involved in modulating neurotransmission, inflammation, and cell proliferation. NTSR1 is highly expressed in the central nervous system (CNS), particularly in the hypothalamus, midbrain, and limbic structures, where it regulates dopamine signaling, thermoregulation, and nociception. NTSR1 couples to Gq/11 proteins, activating phospholipase C (PLC), increasing intracellular calcium, and stimulating downstream pathways like MAPK and PI3K/Akt. In the periphery, NTSR1 is expressed in the gastrointestinal tract and immune cells, where it regulates gut motility, inflammation, and pain perception. Dysregulation of NTSR1 signaling is associated with neurological disorders, schizophrenia, cancer progression, and chronic pain. NTSR1 agonists are being explored for their neuroprotective and analgesic effects, while NTSR1 antagonists are being investigated for treating cancer due to the receptor’s role in promoting tumor cell proliferation and survival.

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