Human Neurotensin Receptor 1, High Affinity (NTSR1) CLIA Kit
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Description
Human Neurotensin Receptor 1, High Affinity (NTSR1) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Neurotensin Receptor 1, High Affinity (NTSR1) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.061 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P30989 |
| Alias | NTSR1,NTR,NTR1,NTRH,neurotensin receptor type 1, Levocabastin-insensitive neurotensin receptor,NT-1R,neurotensin receptor 1 (high affinity) |
| Background | CLIA Kits NTSR1 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
NTSR1 is a G protein-coupled receptor that binds neurotensin (NT), a neuropeptide involved in modulating neurotransmission, inflammation, and cell proliferation. NTSR1 is highly expressed in the central nervous system (CNS), particularly in the hypothalamus, midbrain, and limbic structures, where it regulates dopamine signaling, thermoregulation, and nociception. NTSR1 couples to Gq/11 proteins, activating phospholipase C (PLC), increasing intracellular calcium, and stimulating downstream pathways like MAPK and PI3K/Akt. In the periphery, NTSR1 is expressed in the gastrointestinal tract and immune cells, where it regulates gut motility, inflammation, and pain perception. Dysregulation of NTSR1 signaling is associated with neurological disorders, schizophrenia, cancer progression, and chronic pain. NTSR1 agonists are being explored for their neuroprotective and analgesic effects, while NTSR1 antagonists are being investigated for treating cancer due to the receptor’s role in promoting tumor cell proliferation and survival.
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