Human Metabotropic Glutamate Receptor 6 (GRM6) Cell ELISA Kit
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Description
mGluR6 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Metabotropic Glutamate Receptor 6 (GRM6) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O15303 |
| Gene ID | 2916 |
| OMIM | 257270 |
| Alias | GRM6,CSNB1B,GPRC1F,MGLUR6,mGlu6,nob4,nerg1,nob2,nob3 |
| Background | Elisa kits for GRM6 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GRM6, or mGluR6, is a Group III metabotropic glutamate receptor primarily expressed in the retina, where it plays a critical role in visual signal transmission. GRM6 is located on the dendrites of ON bipolar cells, where it couples to Gi/o proteins to inhibit adenylate cyclase, reducing cAMP levels. This pathway is essential for detecting light changes and relaying visual signals from photoreceptors to the brain. Mutations in the GRM6 gene are associated with congenital stationary night blindness (CSNB), a condition characterized by impaired night vision and abnormal signal transduction in the retina. Beyond its role in vision, GRM6 may have limited expression in the CNS, where it could contribute to inhibitory neurotransmission. Given its specialized function in the retina, GRM6 represents a key target for understanding retinal disorders and developing therapies to restore visual signaling in hereditary visual impairments.
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