Human Lysophosphatidic Acid Receptor 4 (LPAR4) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for LPAR4
proveedor
Abbexareference
abx253944Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Lysophosphatidic Acid Receptor 4 (LPAR4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Lysophosphatidic acid receptor 4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
LPAR4 is a G protein-coupled receptor for lysophosphatidic acid (LPA) that preferentially couples to G12/13 and Gq proteins, influencing cytoskeletal organization, calcium signaling, and cell migration. LPAR4 is expressed in hematopoietic cells, endothelial cells, and certain epithelial tissues, where it regulates cell adhesion, proliferation, and vascular development. Unlike other LPA receptors, LPAR4 has been implicated in blood vessel stability and lymphocyte trafficking, playing a role in vascular homeostasis and immune cell regulation. LPAR4 activation contributes to endothelial barrier function and vascular remodeling, making it relevant in conditions such as vascular inflammation and atherosclerosis. In cancer, LPAR4’s role is less well characterized compared to other LPA receptors, but it has been linked to cell migration and metastasis in certain malignancies. Dysregulation of LPAR4 signaling is associated with vascular disorders and immune dysfunction. Targeting LPAR4 offers therapeutic potential for vascular diseases, immune modulation, and cancer progression, highlighting its emerging role in LPA-mediated signaling pathways.
Características del producto
category
ELISA Kits
immunogen target
Lysophosphatidic Acid Receptor 4 (LPAR4)
reactivity
Human
test range
0.312 ng/ml - 20 ng/ml
sensitivity
< 0.12 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
LPAR4,GPR23,LPA4,P2RY9,P2Y5-LIKE,P2Y9,P2Y5-like receptor,G protein-coupled receptor 23,LPA receptor 4,P2Y,purinoceptor 9,Purinergic receptor 9
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
LPAR4
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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