Human LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) ELISA Kit
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Description
Human LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human LIM And Senescent Cell Antigen Like Domains Protein 1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | LIMS1,PINCH,INCH1,PINCH-1,LIM and senescent cell antigen-like-containing domain protein 1 |
| Background | Elisa kits for LIMS1 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
LIMS1, also known as PINCH1 (Particularly Interesting New Cysteine-Histidine rich protein), is a LIM domain-containing adaptor protein involved in integrin-mediated cell adhesion and signaling. LIMS1 interacts with focal adhesion proteins such as ILK (integrin-linked kinase) and acts as a scaffold to regulate cell-ECM adhesion, cytoskeletal organization, and signaling pathways like PI3K/Akt, MAPK/ERK, and TGF-β. It is broadly expressed in tissues and plays critical roles in cell survival, migration, differentiation, and embryonic development. LIMS1 is essential for cardiac and skeletal muscle development, where it stabilizes focal adhesions and modulates mechanical signaling. Dysregulation of LIMS1 is associated with cancer progression, metastasis, and fibrosis due to its role in integrin signaling and actin cytoskeleton remodeling. Knockout models show embryonic lethality, severe developmental defects, and impaired adhesion, highlighting its importance in tissue homeostasis.
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