LTB4R antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
LTB4R antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04884
tested applications
ELISA, IHC
Description
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | leukotriene B4 receptor (LTB4R) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q15722 |
| Gene ID | 1241 |
| Alias | LTB4R,BLT1,BLTR,CMKRL1,GPR16,LTB4R1,LTBR1,P2RY7,P2Y7,BLTR,GPR16 |
| Background | Antibody anti-LTB4R |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
LTB4R, also known as BLT1, is a high-affinity G protein-coupled receptor for leukotriene B4 (LTB4), a potent lipid mediator derived from arachidonic acid. It is predominantly expressed on immune cells, such as neutrophils, monocytes, and T cells, where it regulates inflammatory responses and immune cell recruitment. Upon LTB4 binding, LTB4R activates downstream signaling pathways, including PI3K/Akt and MAPK, which promote chemotaxis, cytokine production, and reactive oxygen species (ROS) generation. LTB4R plays a critical role in acute and chronic inflammation, contributing to diseases such as asthma, rheumatoid arthritis, and inflammatory bowel disease (IBD). In cancer, LTB4R has been linked to tumor progression and metastasis by enhancing immune cell infiltration and angiogenesis within the tumor microenvironment. Dysregulated LTB4R signaling is also implicated in cardiovascular and metabolic disorders. Therapeutically, LTB4R antagonists are being developed to treat inflammatory and immune-mediated diseases by suppressing leukotriene B4-mediated responses, making it a key target for inflammation modulation.
Related Products
Human LTB4R (Leukotriene B4 receptor 1) ELISA Kit
Ver Producto
Rat LTB4R (Leukotriene B4 receptor 1) ELISA Kit
Ver Producto
LTB4R antibody
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Ver Producto