Human Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Protein
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935106861
info@markelab.com
Precio
208€ (10 µg)
Protein LGR5
proveedor
Abbexareference
abx652237Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Protein is a Recombinant protein from Human.
Background
LGR5 is another member of the LGR family, closely associated with stem cell maintenance and tissue regeneration. It is highly expressed in adult stem cells of various tissues, including the intestines, hair follicles, and the mammary gland. LGR5 is a key player in regulating Wnt signaling, a pathway that controls stem cell proliferation, self-renewal, and differentiation. In the intestines, LGR5+ stem cells are essential for maintaining the intestinal epithelium and enabling tissue regeneration after injury. LGR5 is also involved in the formation and progression of tumors, particularly in colorectal cancer, where LGR5+ cells contribute to tumor initiation and metastasis. Research into LGR5 is actively exploring its role as a biomarker for cancer and its potential as a target for cancer therapies that aim to disrupt the Wnt signaling pathway and inhibit tumor growth. Additionally, LGR5 is being studied for its role in tissue repair and stem cell therapies.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 25.2 kDa Observed MW (SDS-PAGE): 25 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys107-Val296 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
LGR5
dry ice
No
availability
Shipped within 5-7 working days.
alias
LGR5,GPR49,FEX,GPR67,orphan G protein-coupled receptor HG38,leucine-rich repeat-containing G protein-coupled receptor 5,leucine-rich repeat containing G protein-coupled receptor 5
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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