anti- LGR5 antibody

Descripción

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Características del producto

clonality

polyclonal

reactivity

human

immunogen target

leucine-rich repeat-containing G protein-coupled receptor 5

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, IHC

observerd MW

100kd

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

IHC: 1:100-1:400

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

LGR5

alias

LGR5,GPR49,FEX,GPR67,orphan G protein-coupled receptor HG38,leucine-rich repeat-containing G protein-coupled receptor 5,leucine-rich repeat containing G protein-coupled receptor 5

uniprot id

https://www.uniprot.org/uniprotkb/O75473

gene id

https://www.ncbi.nlm.nih.gov/gene/8549

note

This product is for research use only.

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Tested Applications

reactivity

status

clonality

Descripción

Características del producto

category

clonality

reactivity

immunogen target

host

isotype

conjugation

form

tested applications

observerd MW

purity

purification

recommended dilution

size 1

storage

or code

alias

uniprot id

gene id

note

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reference

reactivity

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Mouse LGR-5(leucine-rich repeat-containing g-protein coupled receptor 5) ELISA Kit

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reactivity

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Rat LGR-5(leucine-rich repeat-containing g-protein coupled receptor 5) ELISA Kit

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reactivity

status