Human Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 4 (LGR4) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 4 (LGR4) Protein is a recombinant Human protein produced in a Mammalian cell expression system.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 4 (LGR4) |
| Host | Mammalian cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Thr544 Tag: C-terminal Fc tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 85.79 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20 °C to 80°C. Avoid repeated freeze-thaw cycles. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q9BXB1 |
| Alias | LGR4,GPR48,leucine-rich repeat-containing G protein-coupled receptor 4,leucine-rich repeat containing G protein-coupled receptor 4,DPSL,BNMD17 |
| Background | Protein LGR4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile water to produce a stock solution. |
Descripción
Related Products
Human LGR4 (Leucine-rich repeat-containing G-protein coupled receptor 4) ELISA Kit
Ver Producto
LGR4 antibody
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin(NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP(By similarity).
Ver Producto