Human Leucine Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human Leucine Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Leucine-rich repeat-containing G-protein coupled receptor 4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Leucine Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.625 ng/ml - 40 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9BXB1 |
| Alias | LGR4,GPR48,leucine-rich repeat-containing G protein-coupled receptor 4,leucine-rich repeat containing G protein-coupled receptor 4,DPSL,BNMD17 |
| Background | Elisa kits for LGR4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
LGR4 is a member of the leucine-rich repeat-containing G protein-coupled receptor (LGR) family, which is activated by R-spondins, a group of proteins that regulate Wnt signaling. LGR4 plays a significant role in tissue development, differentiation, and homeostasis, particularly in the epithelial cells of various organs, including the gastrointestinal tract, kidney, and skin. It is involved in modulating Wnt/β-catenin signaling pathways, which are crucial for cell proliferation, stem cell maintenance, and differentiation. LGR4 is implicated in regulating processes such as embryogenesis, organogenesis, and tissue repair. Dysregulation of LGR4 signaling has been associated with conditions like cancer, particularly colorectal cancer, and disorders of tissue regeneration. LGR4 also plays a role in controlling blood pressure and fluid balance, with potential therapeutic applications in hypertension and renal diseases.
Related Products
Human LGR4 (Leucine-rich repeat-containing G-protein coupled receptor 4) ELISA Kit
Ver Producto
LGR4 antibody
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin(NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP(By similarity).
Ver Producto