Human Latrophilin 3 / LPHN3 (ADGRL3) Protein
221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Latrophilin 3 / LPHN3 (ADGRL3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166734
tested applications
WB, SDS-PAGE
Description
Human Latrophilin 3 / LPHN3 (ADGRL3) Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Latrophilin 3 / LPHN3 (ADGRL3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 41.7 kDa Observed MW (SDS-PAGE): 42 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln1105-Leu1447 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HAR2 |
| Alias | ADGRL3,CL3,LEC3,CIRL3,LPHN3,latrophilin 3,calcium-independent receptor of alpha-latrotoxin 3,LEC3,Lectomedin-3,CL3,CIRL/latrophilin 3 |
| Background | Protein ADGRL3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ADGRL3, also referred to as Latrophilin-3, is primarily expressed in the central nervous system and plays a pivotal role in neural circuit formation, synaptic development, and plasticity. Its interaction with neuronal ligands facilitates trans-synaptic adhesion, critical for the regulation of synaptic strength and maintenance of neural connectivity. ADGRL3 is implicated in neuropsychiatric and developmental disorders, with genetic mutations linked to conditions such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders. It regulates intracellular signaling pathways involved in neuronal differentiation and synaptic maturation, underscoring its role in both developmental and functional aspects of the nervous system. Dysregulation of ADGRL3 can lead to altered neuronal communication, impacting behavior, cognition, and overall neurological health.
Related Products
anti- LPHN3 antibody
Ver Producto
Latrophilin 3 / LPHN3 (ADGRL3) Antibody
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.
Ver Producto
Latrophilin 3 / LPHN3 (ADGRL3) Antibody
Latrophilin 3 / LPHN3 (ADGRL3) Antibody is a Rabbit Polyclonal against Latrophilin 3 / LPHN3 (ADGRL3).
Ver Producto