Latrophilin 3 / LPHN3 (ADGRL3) Antibody
637€ (100 µl)
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Name
Latrophilin 3 / LPHN3 (ADGRL3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx113444
Tested Applications
ELISA, WB
Description
Latrophilin 3 / LPHN3 (ADGRL3) Antibody is a Rabbit Polyclonal against Latrophilin 3 / LPHN3 (ADGRL3).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Latrophilin 3 / LPHN3 (ADGRL3) Immunogen: Human LPHN3. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HAR2 |
| Gene ID | 23284 |
| NCBI Accession | NP_001309175.1, NM_001322246.1 |
| OMIM | 616417 |
| Alias | ADGRL3,CL3,LEC3,CIRL3,LPHN3,latrophilin 3,calcium-independent receptor of alpha-latrotoxin 3,LEC3,Lectomedin-3,CL3,CIRL/latrophilin 3 |
| Background | Antibody anti-ADGRL3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADGRL3, also referred to as Latrophilin-3, is primarily expressed in the central nervous system and plays a pivotal role in neural circuit formation, synaptic development, and plasticity. Its interaction with neuronal ligands facilitates trans-synaptic adhesion, critical for the regulation of synaptic strength and maintenance of neural connectivity. ADGRL3 is implicated in neuropsychiatric and developmental disorders, with genetic mutations linked to conditions such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders. It regulates intracellular signaling pathways involved in neuronal differentiation and synaptic maturation, underscoring its role in both developmental and functional aspects of the nervous system. Dysregulation of ADGRL3 can lead to altered neuronal communication, impacting behavior, cognition, and overall neurological health.
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