Human Karyopherin Alpha 2 (KPNA2) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for KPNA2
proveedor
Abbexareference
abx250558Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Karyopherin Alpha 2 (KPNA2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Importin subunit alpha-2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
KPNA2, also known as importin-α2, is a key nuclear transport adaptor protein that binds cargo proteins containing classical nuclear localization signals (NLS). It works in conjunction with importin-β to translocate the cargo through the nuclear pore complex (NPC) into the nucleus. KPNA2 is ubiquitously expressed and is involved in processes like gene expression, DNA repair, and cell proliferation. It has been shown to play a significant role in cancer biology, where overexpression of KPNA2 is associated with tumor progression, metastasis, and poor prognosis in cancers such as breast, lung, and liver cancers. KPNA2 also facilitates the nuclear import of viral proteins, making it a target in viral pathogenesis. Knockout studies indicate that KPNA2 is essential for cell viability and differentiation, particularly during embryogenesis and immune cell development.
Características del producto
category
ELISA Kits
immunogen target
Karyopherin Alpha 2 (KPNA2)
reactivity
Human
test range
0.312 ng/ml - 20 ng/ml
sensitivity
< 0.21 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
KPNA2,IPOA1, QIP2, RCH1, SRP1alpha, Karyopherin alpha 2, SRP1-alpha, karyopherin subunit alpha 2, PTAC58
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
KPNA2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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