Human Karyopherin Alpha 2 (KPNa2) Protein

Este producto es parte de KPNA - karyopherin subunit alpha
Human Karyopherin Alpha 2 (KPNa2) Protein
234€ (10 µg)

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Name
Human Karyopherin Alpha 2 (KPNa2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx067600
Tested Applications
WB, SDS-PAGE

Description

Human Karyopherin Alpha 2 (KPNa2) is a recombinant Human protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Karyopherin Alpha 2 (KPNa2)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Ala157-Gln412
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 31.0 kDa  Observed MW (SDS-PAGE): 27 kDa
Expression
Recombinant
Purity
> 97%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
P52292
Alias
KPNA2,IPOA1, QIP2, RCH1, SRP1alpha, Karyopherin alpha 2, SRP1-alpha, karyopherin subunit alpha 2, PTAC58
Background
Protein KPNA2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

KPNA2, also known as importin-α2, is a key nuclear transport adaptor protein that binds cargo proteins containing classical nuclear localization signals (NLS). It works in conjunction with importin-β to translocate the cargo through the nuclear pore complex (NPC) into the nucleus. KPNA2 is ubiquitously expressed and is involved in processes like gene expression, DNA repair, and cell proliferation. It has been shown to play a significant role in cancer biology, where overexpression of KPNA2 is associated with tumor progression, metastasis, and poor prognosis in cancers such as breast, lung, and liver cancers. KPNA2 also facilitates the nuclear import of viral proteins, making it a target in viral pathogenesis. Knockout studies indicate that KPNA2 is essential for cell viability and differentiation, particularly during embryogenesis and immune cell development.

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