Human Interleukin 6 (IL6) Protein
494€ (20 µg)
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Name
Human Interleukin 6 (IL6) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx670173
Tested Applications
ELISA, WB
Description
Human Interleukin 6 (IL6) Protein is a Recombinant protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 6 (IL6) |
| Host | E. coli |
| Assay Type | Sequence Fragment: Full length (184 AA). |
| Recommended Dilution | ELISA: 0.2-0.4 ng/well, WB: 1.5-3.0 ng/lane, Functional Assays: 0.1-10 ng/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | 20.9 kDa |
| Purity | > 98% (SDS-PAGE and HPLC) |
| Size 1 | 20 µg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Does not contain preservatives. |
| Availability | Shipped within 3-7 working days. |
| Storage | Store at -20 °C after reconstitution. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05231 |
| Alias | IL-6,BSF,HGF,HSF,IFNB2,CDF,B-cell stimulatory factor 2 |
| Background | Protein IL6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in distilled water to a concentration of 0.1 mg/ml (for the 5 µg size, add 50 µl distilled water; for the 20 µg size, add 200 µl distilled water). Do not vortex. For long term storage the addition of 0.1% bovine serum albumin (BSA) is recommended. Endotoxin Level: < 0.1 ng/µg |
Background
IL6 is a pleiotropic cytokine involved in regulating immune responses, inflammation, and hematopoiesis It is produced by macrophages, T cells, fibroblasts, and endothelial cells in response to infections, trauma, or tissue damage IL6 activates downstream signaling through its receptor, IL-6R, and the JAK/STAT3 pathway, driving acute-phase protein synthesis, such as CRP and fibrinogen, and promoting B cell differentiation into plasma cells Dysregulated IL6 expression is associated with chronic inflammation, autoimmune diseases like rheumatoid arthritis, and cancer progression, where it promotes tumor growth, survival, and angiogenesis IL6 also contributes to cytokine storm syndrome in conditions like COVID-19, where excessive IL6 leads to hyperinflammation and organ damage Targeting IL6 signaling with anti-IL6 therapies, such as tocilizumab, has shown efficacy in treating autoimmune diseases and cytokine-driven conditions
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