Human Interleukin 6 (IL6) Protein

Este producto es parte de IL6 - Interleukin 6
Human Interleukin 6 (IL6) Protein

Pida mas información

935106861

info@markelab.com

Precio

481€ (20 µg)

Protein IL6

proveedor

Abbexa

reference

abx670173

Tested Applications

ELISA, WB

reactivity

status

RUO

clonality

Descripción

Human Interleukin 6 (IL6) Protein is a Recombinant protein expressed in E. coli.

Background

IL6 is a pleiotropic cytokine involved in regulating immune responses, inflammation, and hematopoiesis It is produced by macrophages, T cells, fibroblasts, and endothelial cells in response to infections, trauma, or tissue damage IL6 activates downstream signaling through its receptor, IL-6R, and the JAK/STAT3 pathway, driving acute-phase protein synthesis, such as CRP and fibrinogen, and promoting B cell differentiation into plasma cells Dysregulated IL6 expression is associated with chronic inflammation, autoimmune diseases like rheumatoid arthritis, and cancer progression, where it promotes tumor growth, survival, and angiogenesis IL6 also contributes to cytokine storm syndrome in conditions like COVID-19, where excessive IL6 leads to hyperinflammation and organ damage Targeting IL6 signaling with anti-IL6 therapies, such as tocilizumab, has shown efficacy in treating autoimmune diseases and cytokine-driven conditions

Características del producto

category

Proteins and Peptides

origin

Human

host

E. coli

immunogen target

Interleukin 6 (IL6)

host

E. coli

conjugation

Unconjugated

form

Lyophilized Reconstitute in distilled water to a concentration of 0.1 mg/ml (for the 5 µg size, add 50 µl distilled water; for the 20 µg size, add 200 µl distilled water). Do not vortex. For long term storage the addition of 0.1% bovine serum albumin (BSA) is recommended.

tested applications

ELISA, WB

size 1

20 µg

observerd MW

Molecular Weight: 20.9 kDa Sequence Fragment: Full length (184 AA).

purity

> 98% (SDS-PAGE and HPLC)

recommended dilution

ELISA: 0.2-0.4 ng/well, WB: 1.5-3.0 ng/lane, Functional Assays: 0.1-10 ng/ml. Optimal dilutions/concentrations should be determined by the end user.

buffer

Does not contain preservatives.

storage

Store at -20 °C after reconstitution. Avoid repeated freeze/thaw cycles.

or code

IL6

dry ice

No

availability

Shipped within 3-7 working days.

alias

IL-6,BSF,HGF,HSF,IFNB2,CDF,B-cell stimulatory factor 2

uniprot id

https://www.uniprot.org/uniprotkb/P05231

note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Quizá le pueda interesar

Human HS-IL-6(High sensitive Interleukin 6) Accquant® ELISA Kit

Human HS-IL-6(High sensitive Interleukin 6) Accquant® ELISA Kit

proveedor

FineTest

reference

AQ-H0201

reactivity

human

status

RUO

Precio a consultar

Ver más

Human HS-IL-6(High sensitive Interleukin 6) Accquant® ELISA Kit

Human HS-IL-6(High sensitive Interleukin 6) Accquant® ELISA Kit

proveedor

FineTest

reference

AQ-H0201-B

reactivity

human

status

RUO

Precio a consultar

Ver más

Mouse HS-IL-6(High sensitive Interleukin 6) Accquant® ELISA Kit

Mouse HS-IL-6(High sensitive Interleukin 6) Accquant® ELISA Kit

proveedor

FineTest

reference

AQ-M0121-B

reactivity

mouse

status

RUO

Precio a consultar

Ver más