Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) Protein
234€ (10 µg)
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935106861
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name
Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167958
tested applications
WB, SDS-PAGE
Description
Interleukin 1 Receptor Accessory Protein Like Protein 2 is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 23.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser161-Thr330 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | IL1RAPL2,IL-1R9, IL1R9, IL1RAPL-2, TIGIRR-1 |
| Background | Protein IL1RAPL2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL1RAPL2 is a structurally related protein in the IL-1 receptor family that exhibits specialized functions in neuronal signaling, synaptic development, and immune regulation. It shares similarities with IL1RAP but has distinct patterns of expression, being predominantly found in developing neurons and immune cells. IL1RAPL2 interacts with downstream effectors to regulate cytokine signaling, dendritic spine formation, and synaptic plasticity, influencing neurodevelopment and immune modulation. In neurons, IL1RAPL2 promotes excitatory synapse formation and dendrite maturation, which are critical for cognitive function, neuronal communication, and brain connectivity. Dysregulation or mutations in IL1RAPL2 have been associated with neurodevelopmental disorders, including autism spectrum disorders and intellectual disabilities, where altered neuronal connectivity and synaptic function contribute to cognitive impairment and behavioral deficits. Knockdown models exhibit reduced synaptic development, defective dendritic growth, and impaired immune signaling, highlighting its importance in balancing neurodevelopment, synaptic organization, and immune responses.
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