Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) CLIA Kit
845€ (96 tests)
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935106861
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name
Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx190226
tested applications
CLIA
Description
Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 13.7 pg/ml - 10000 pg/ml |
| Sensitivity | < 5.4 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | IL1RAPL2,IL-1R9, IL1R9, IL1RAPL-2, TIGIRR-1 |
| Background | CLIA Kits IL1RAPL2 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IL1RAPL2 is a structurally related protein in the IL-1 receptor family that exhibits specialized functions in neuronal signaling, synaptic development, and immune regulation. It shares similarities with IL1RAP but has distinct patterns of expression, being predominantly found in developing neurons and immune cells. IL1RAPL2 interacts with downstream effectors to regulate cytokine signaling, dendritic spine formation, and synaptic plasticity, influencing neurodevelopment and immune modulation. In neurons, IL1RAPL2 promotes excitatory synapse formation and dendrite maturation, which are critical for cognitive function, neuronal communication, and brain connectivity. Dysregulation or mutations in IL1RAPL2 have been associated with neurodevelopmental disorders, including autism spectrum disorders and intellectual disabilities, where altered neuronal connectivity and synaptic function contribute to cognitive impairment and behavioral deficits. Knockdown models exhibit reduced synaptic development, defective dendritic growth, and impaired immune signaling, highlighting its importance in balancing neurodevelopment, synaptic organization, and immune responses.
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