Human Interferon-Induced GTP-Binding Protein Mx1 (MX1) Protein

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Description
Human MX1 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Interferon-Induced GTP-Binding Protein Mx1 (MX1) |
Host | E. coli |
Origin | Human |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 30.6 kDa Observed MW (SDS-PAGE): 34 kDa Possible reasons why the actual band size differs from the predicted band size: 1. Splice variants. Alternative splicing may create different sized proteins from the same gene. 2. Relative charge. The composition of amino acids may affect the charge of the protein. 3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size. 4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form. 5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed. Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser80-Leu342 Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 95% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P20591 |
Alias | Interferon-induced protein p78,IFI-78K,Interferon-induced GTP-binding protein Mx1,MXA |
Background | Protein MX1 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
MX dynamin-like GTPase 1 (MX1), also known as myxovirus resistance protein 1, is a key component of the innate immune response against viral infections. MX1 belongs to the dynamin family of GTPases and exhibits antiviral activity by interfering with the replication of a wide range of RNA viruses, including influenza and vesicular stomatitis viruses. MX1 exerts its effects by targeting viral nucleocapsids, preventing their transport and replication within host cells. MX1 is induced by type I interferons (IFNs), such as IFN-alpha and IFN-beta, upon viral infection. Its GTPase activity is essential for its antiviral function, facilitating conformational changes required to entrap viral components. The protein localizes to the cytoplasm and assembles into ring-like structures, further enhancing its antiviral activity. MX1 is considered a biomarker for interferon signaling and has potential applications in antiviral therapies.
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