Human Integrin Alpha M / CD11b (ITGAM) Protein
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935106861
info@markelab.com
Precio
247€ (10 µg)
Protein ITGAM
proveedor
Abbexareference
abx168291Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Integrin alpha M (ITGAM) Protein is a recombinant Human protein produced in a prokaryotic expression system (E. coli).
Background
Integrin Subunit Alpha M (ITGAM), also known as CD11b, is a transmembrane glycoprotein expressed predominantly on the surface of monocytes, macrophages, granulocytes, and some dendritic cells. ITGAM forms a heterodimer with integrin beta-2 (ITGB2) to create the Mac-1 complex, which is crucial in mediating adhesion and migration of leukocytes during inflammatory and immune responses. The protein plays a pivotal role in immune surveillance and host defense by facilitating phagocytosis, complement receptor activity, and migration across endothelial barriers. Additionally, ITGAM is involved in the recognition and clearance of pathogens and apoptotic cells. Aberrations in ITGAM expression or mutations have been linked to systemic lupus erythematosus (SLE) and other autoimmune disorders. It is also a key player in immune evasion mechanisms employed by certain pathogens.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Integrin Alpha M / CD11b (ITGAM)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 17.9 kDa Observed MW (SDS-PAGE): 18 kDa Concentration: Prior to lyophilization: 300 µg/ml Sequence Fragment: Asn301-Thr451 Tag: N-terminal His tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ITGAM
dry ice
No
availability
Shipped within 5-12 working days.
alias
CR3A,MO1A,CD11B,MAC-1,MAC1A,SLEB6,CD11 antigen-like family member B,CR-3 alpha chain,Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,Neutrophil adherence receptor
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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