Human Insulin Receptor (INSR) Protein
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Description
Human Insulin Receptor (INSR) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Insulin Receptor (INSR) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 39.6 kDa Observed MW (SDS-PAGE): 39 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg1027-Met1364 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06213 |
| Gene ID | 3643 |
| OMIM | 125853 |
| Alias | HHF5,CD220,IR |
| Background | Protein INSR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The insulin receptor (INSR) is a transmembrane protein essential for regulating glucose homeostasis, cellular growth, and metabolism. This receptor, which belongs to the receptor tyrosine kinase (RTK) family, is the primary signaling molecule for insulin, a hormone central to controlling blood sugar levels. By binding insulin, the INSR initiates a cascade of signaling pathways that drive glucose uptake, protein synthesis, lipid metabolism, and cell proliferation. Dysregulation of INSR signaling is implicated in various metabolic and endocrine diseases, most notably type 2 diabetes mellitus (T2DM), obesity, and insulin resistance-related disorders. The receptor’s role in modulating these critical physiological processes makes it a focus for therapeutic interventions and research in metabolic diseases.
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