Human Cis-Aconitate Decarboxylase (ACOD1) ELISA Kit

Este producto es parte de ACOD1 - Cis-aconitate decarboxylase
Human Cis-Aconitate Decarboxylase (ACOD1) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for ACOD1

proveedor

Abbexa

reference

abx528644

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Cis-Aconitate Decarboxylase (ACOD1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Cis-Aconitate Decarboxylase (ACOD1) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

Cis-aconitate decarboxylase (ACOD1), also known as immune-responsive gene 1 (IRG1), is an enzyme that converts cis-aconitate, an intermediate of the TCA cycle, into itaconate. Itaconate is a key immunometabolite with anti-inflammatory and antimicrobial properties, as it modulates cellular metabolism and inhibits the activity of pro-inflammatory enzymes like succinate dehydrogenase. ACOD1 is highly expressed in macrophages and other immune cells in response to inflammatory signals, such as lipopolysaccharide (LPS), playing a critical role in the metabolic reprogramming of immune responses. Dysregulation of ACOD1 has been implicated in inflammatory diseases and infections, with itaconate production acting as a protective mechanism against oxidative stress and pathogen growth. Its therapeutic potential is being investigated for modulating inflammation and treating immune-related disorders.

Características del producto

category

ELISA Kits


immunogen target

Cis-Aconitate Decarboxylase (ACOD1)


reactivity

Human


test range

78 pg/ml - 5000 pg/ml


sensitivity

< 25.5 pg/ml


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

CAD,IRG1,Immune-responsive gene 1 protein


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

ACOD1


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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