Cis-Aconitate Decarboxylase (ACOD1) Antibody

Background

Cis-aconitate decarboxylase (ACOD1), also known as immune-responsive gene 1 (IRG1), is an enzyme that converts cis-aconitate, an intermediate of the TCA cycle, into itaconate. Itaconate is a key immunometabolite with anti-inflammatory and antimicrobial properties, as it modulates cellular metabolism and inhibits the activity of pro-inflammatory enzymes like succinate dehydrogenase. ACOD1 is highly expressed in macrophages and other immune cells in response to inflammatory signals, such as lipopolysaccharide (LPS), playing a critical role in the metabolic reprogramming of immune responses. Dysregulation of ACOD1 has been implicated in inflammatory diseases and infections, with itaconate production acting as a protective mechanism against oxidative stress and pathogen growth. Its therapeutic potential is being investigated for modulating inflammation and treating immune-related disorders.