Cis-Aconitate Decarboxylase (ACOD1) Antibody (FITC)
169€ (20 µg)
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935106861
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name
Cis-Aconitate Decarboxylase (ACOD1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx312844
Description
Cis-Aconitate Decarboxylase (ACOD1) Antibody (FITC) is a Rabbit Polyclonal against Cis-Aconitate Decarboxylase (ACOD1) conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cis-Aconitate Decarboxylase (ACOD1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | A6NK06 |
| Gene ID | 730249 |
| OMIM | 615275 |
| Alias | CAD,IRG1,Immune-responsive gene 1 protein |
| Background | Antibody anti-ACOD1 |
| Status | RUO |
| Note | Concentration: 0.25 mg/ml - |
Descripción
Cis-aconitate decarboxylase (ACOD1), also known as immune-responsive gene 1 (IRG1), is an enzyme that converts cis-aconitate, an intermediate of the TCA cycle, into itaconate. Itaconate is a key immunometabolite with anti-inflammatory and antimicrobial properties, as it modulates cellular metabolism and inhibits the activity of pro-inflammatory enzymes like succinate dehydrogenase. ACOD1 is highly expressed in macrophages and other immune cells in response to inflammatory signals, such as lipopolysaccharide (LPS), playing a critical role in the metabolic reprogramming of immune responses. Dysregulation of ACOD1 has been implicated in inflammatory diseases and infections, with itaconate production acting as a protective mechanism against oxidative stress and pathogen growth. Its therapeutic potential is being investigated for modulating inflammation and treating immune-related disorders.
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