Human Hydroxy-Carboxylic Acid Receptor 1 (HCAR1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for HCAR1
proveedor
Abbexareference
abx387655Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Hydroxy-Carboxylic Acid Receptor 1 (HCAR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Hydroxy-Carboxylic Acid Receptor 1 (HCAR1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
HCAR1, also known as GPR81, is a G protein-coupled receptor that responds to lactate, a key metabolite produced during glycolysis. HCAR1 is primarily expressed in adipose tissue, skeletal muscle, and the central nervous system, where it plays a critical role in energy metabolism. Activation of HCAR1 inhibits adenylate cyclase via Gi/o proteins, reducing intracellular cAMP levels and suppressing lipolysis in adipocytes. This action helps conserve energy during periods of high lactate production, such as intense exercise or hypoxia. HCAR1 also regulates metabolic signaling in the liver and brain, where lactate serves as both an energy substrate and signaling molecule. Dysregulation of HCAR1 signaling is associated with metabolic disorders, including obesity, insulin resistance, and type 2 diabetes. Recent studies suggest HCAR1’s involvement in neuroprotection, where lactate signaling may support neuronal survival during metabolic stress. HCAR1 is a promising therapeutic target for metabolic diseases, neuroprotection, and conditions involving excessive lipolysis.
Características del producto
category
ELISA Kits
immunogen target
Hydroxy-Carboxylic Acid Receptor 1 (HCAR1)
reactivity
Human
test range
0.313 ng/ml - 20 ng/ml
sensitivity
< 0.188 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
HCAR1,FKSG80,LACR1,lactate receptor 1,T-cell activation G protein-coupled receptor,G protein-coupled receptor 104,G protein-coupled receptor 81,Gpr81,FKSG80, GPR104, GPR81, HCA1,TA-GPCR, TAGPCR
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
HCAR1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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