G Protein-Coupled Receptor 81 (GPR81) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
G Protein-Coupled Receptor 81 (GPR81) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx028676
tested applications
ELISA, WB
Description
G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | G Protein-Coupled Receptor 81 (GPR81) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BXC0 |
| Alias | HCAR1,FKSG80,LACR1,lactate receptor 1,T-cell activation G protein-coupled receptor,G protein-coupled receptor 104,G protein-coupled receptor 81,Gpr81,FKSG80, GPR104, GPR81, HCA1,TA-GPCR, TAGPCR |
| Background | Antibody anti-HCAR1 |
| Status | RUO |
Descripción
HCAR1, also known as GPR81, is a G protein-coupled receptor that responds to lactate, a key metabolite produced during glycolysis. HCAR1 is primarily expressed in adipose tissue, skeletal muscle, and the central nervous system, where it plays a critical role in energy metabolism. Activation of HCAR1 inhibits adenylate cyclase via Gi/o proteins, reducing intracellular cAMP levels and suppressing lipolysis in adipocytes. This action helps conserve energy during periods of high lactate production, such as intense exercise or hypoxia. HCAR1 also regulates metabolic signaling in the liver and brain, where lactate serves as both an energy substrate and signaling molecule. Dysregulation of HCAR1 signaling is associated with metabolic disorders, including obesity, insulin resistance, and type 2 diabetes. Recent studies suggest HCAR1’s involvement in neuroprotection, where lactate signaling may support neuronal survival during metabolic stress. HCAR1 is a promising therapeutic target for metabolic diseases, neuroprotection, and conditions involving excessive lipolysis.
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