Human GP145-TrkC (TrkC) Protein (Active)

Este producto es parte de NTRK - neurotrophic receptor tyrosine kinase
Human GP145-TrkC (TrkC) Protein (Active)
1118€ (100 µg)

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935106861
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Name
Human GP145-TrkC (TrkC) Protein (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx692619
Tested Applications
SDS-PAGE

Description

Human TrkC Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the extracellular domain (Met1-Asp428) of human TrkC (NP_001007157.1) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category 
Proteins and Peptides
Immunogen Target 
TrkC
Host 
HEK293 cells
Assay Type 
Activity: Active
Sequence Fragment: Met1-Asp428
Tag: C-terminal His tag and Fc tag
Origin 
Human
Observed MW 
72.5 kDa
Expression 
Recombinant
Purity 
> 98% (SDS-PAGE)
Size 1 
100 µg
Form 
Lyophilized
Tested Applications 
SDS-PAGE
Buffer 
Lyophilized from sterile PBS, pH 7.4.
Availability 
Shipped within 5-15 working days.
Storage 
Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.
Dry Ice 
No
NCBI Accession 
NP_001007157.1
Alias 
TRKC,GP145-TrkC,gp145(trkC),TrkC tyrosine kinase,Neurotrophic tyrosine kinase receptor type 3,NT-3 growth factor receptor
Background 
Protein NTRK3
Status 
RUO
Note 
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Endotoxin Level: < 1.0 EU per µg as determined by the LAL method.

Background

Neurotrophic receptor tyrosine kinase 3 (NTRK3), also known as TrkC, binds primarily with neurotrophin-3 (NT-3) and is integral to the proper development and function of both the central and peripheral nervous systems. This receptor promotes neuronal survival, axonal growth, and the guidance of neuronal connections during development. Dysfunctions in NTRK3 signaling pathways are linked to developmental disorders, including autism spectrum disorders and some cancers, such as medulloblastomas. Its role in neurodevelopment and oncology continues to be a focus of significant clinical research.

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