Human Glutathione Hydrolase 1 Proenzyme (GGT1) Protein

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935106861
info@markelab.com
Precio
1872€ (1 mg)
Protein GGT1
proveedor
Abbexareference
abx652161Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Gamma-Glutamyltransferase 1 (gGT1) Protein is a Recombinant protein from Human.
Background
Gamma-Glutamyltransferase 1 (GGT1) is a membrane-bound enzyme that catalyzes the transfer of gamma-glutamyl moieties from glutathione to amino acids and peptides, playing a critical role in glutathione homeostasis and antioxidant defense GGT1 is essential for the breakdown and recycling of glutathione, a key molecule in detoxifying reactive oxygen species (ROS) and maintaining cellular redox balance GGT1 is highly expressed in the kidney, liver, and other epithelial tissues, where it regulates amino acid transport and cellular responses to oxidative stress Dysregulation of GGT1 activity is associated with oxidative damage, inflammation, and metabolic diseases, including liver disorders, cardiovascular disease, and diabetes Elevated GGT1 levels are also observed in cancers such as hepatocellular carcinoma and lung cancer, where they promote tumor progression and chemoresistance through enhanced glutathione metabolism Additionally, GGT1 serves as a biomarker for liver function and oxidative stress-related conditions Its role in glutathione metabolism and cellular redox regulation underscores its importance in maintaining cellular health and defense mechanisms
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Glutathione Hydrolase 1 Proenzyme (GGT1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
observerd MW
Molecular Weight: Calculated MW: 20.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala382-Gly564 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
GGT1
dry ice
No
availability
Shipped within 1-2 months.
alias
GGT,GTG,GGTD,CD224,GGT 1,D22S672,D22S732
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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