Glutathione Hydrolase 1 Proenzyme (GGT1) Antibody
292.5€ (80 µl)
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Name
Glutathione Hydrolase 1 Proenzyme (GGT1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx031227
Tested Applications
ELISA, WB
Description
The enzyme encoded by this gene catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized and some of which may represent pseudogenes. This gene is classified as type I gamma-glutamyltransferase. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Glutathione Hydrolase 1 Proenzyme (GGT1) Immunogen: KLH-conjugated synthetic peptide between 124-152 amino acids from the N-terminal region of human GGT1. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 61.4 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P19440 |
| Alias | GGT,GTG,GGTD,CD224,GGT 1,D22S672,D22S732 |
| Background | Antibody anti-GGT1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Gamma-Glutamyltransferase 1 (GGT1) is a membrane-bound enzyme that catalyzes the transfer of gamma-glutamyl moieties from glutathione to amino acids and peptides, playing a critical role in glutathione homeostasis and antioxidant defense GGT1 is essential for the breakdown and recycling of glutathione, a key molecule in detoxifying reactive oxygen species (ROS) and maintaining cellular redox balance GGT1 is highly expressed in the kidney, liver, and other epithelial tissues, where it regulates amino acid transport and cellular responses to oxidative stress Dysregulation of GGT1 activity is associated with oxidative damage, inflammation, and metabolic diseases, including liver disorders, cardiovascular disease, and diabetes Elevated GGT1 levels are also observed in cancers such as hepatocellular carcinoma and lung cancer, where they promote tumor progression and chemoresistance through enhanced glutathione metabolism Additionally, GGT1 serves as a biomarker for liver function and oxidative stress-related conditions Its role in glutathione metabolism and cellular redox regulation underscores its importance in maintaining cellular health and defense mechanisms
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