Human Glutathione Hydrolase 1 Proenzyme (GGT1) Protein

Este producto es parte de GGT - Gamma-Glutamyltransferase
Human Glutathione Hydrolase 1 Proenzyme (GGT1) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein GGT1

proveedor

Abbexa

reference

abx066748

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Gamma-Glutamyltransferase 1 (gGT1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Gamma-Glutamyltransferase 1 (GGT1) is a membrane-bound enzyme that catalyzes the transfer of gamma-glutamyl moieties from glutathione to amino acids and peptides, playing a critical role in glutathione homeostasis and antioxidant defense GGT1 is essential for the breakdown and recycling of glutathione, a key molecule in detoxifying reactive oxygen species (ROS) and maintaining cellular redox balance GGT1 is highly expressed in the kidney, liver, and other epithelial tissues, where it regulates amino acid transport and cellular responses to oxidative stress Dysregulation of GGT1 activity is associated with oxidative damage, inflammation, and metabolic diseases, including liver disorders, cardiovascular disease, and diabetes Elevated GGT1 levels are also observed in cancers such as hepatocellular carcinoma and lung cancer, where they promote tumor progression and chemoresistance through enhanced glutathione metabolism Additionally, GGT1 serves as a biomarker for liver function and oxidative stress-related conditions Its role in glutathione metabolism and cellular redox regulation underscores its importance in maintaining cellular health and defense mechanisms

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Glutathione Hydrolase 1 Proenzyme (GGT1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 21.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser122-Ser299 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

GGT1


dry ice

No


availability

Shipped within 5-12 working days.


alias

GGT,GTG,GGTD,CD224,GGT 1,D22S672,D22S732


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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